“New Genetic Mutation Found Associated with Autism - eMaxHealth.com” plus 1 more |
| New Genetic Mutation Found Associated with Autism - eMaxHealth.com Posted: 10 May 2010 08:46 AM PDT Autism, which affects about one in 110 children in the United States, has no known or established cause, but new research from Princeton University and Penn State College of Medicine may have uncovered two genes that may be involved. Senior author Daniel Notterman MD, professor of pediatrics, biochemistry and molecular biology at Penn State, says that their new findings adds to the growing evidence that there are genetic links for autism, but does not rule out a role for environmental causes. "Over the last couple of years, beginning in 2007, it's become clear that some cases of autism, maybe up to 15%, will be caused by rare mutations, either occurring spontaneously or that can be inherited by a parent," he says. Notterman and study co-author Ning Lei PhD of Princeton analyzed data from the Autism Genetic Resource Exchange (AGRE) on 943 families, most of whom had more than one child diagnosed with autism and had undergone genetic testing. The researchers compared the prevalence of 25 gene mutations between the study group as compared to a control group of over 6,300 individuals without developmental or neuropsychiatric illness. They then narrowed their focus on four genes, two of which are already known to be associated with autism because they are involved in forming or maintaining neural synapses. One of the new genes identified by the research, presented at the Pediatric Academic Societies (PAS) annual meeting in Vancouver on May 2, is called Neural Cell Adhesion Molecule 2, or NCAM2. This gene is expressed in the hippocampus and the cerebellum of the brain, regions associated with autism. The genetic mutation of NCAM2 is probably rare, Notterman says. "We would estimate that 0.5% or fewer of kids with autism have the NCAM2 [mutation]." The study also showed that family members of children with autism may carry the NCAM2 mutation, but do not have the disorder themselves, indicating other environmental or genetic factors are involved. A second gene, called PTPRD, was also found to be associated with autism, however Notterman said "We are more confident about NCAM2 and less about PTPRD." Five Filters featured article: The Art of Looking Prime Ministerial - The 2010 UK General Election. Available tools: PDF Newspaper, Full Text RSS, Term Extraction. This posting includes an audio/video/photo media file: Download Now |
| Cant i get help by the goverment as a cargiver for my ... - HealthCentral.com Posted: 10 May 2010 07:13 AM PDT Im a single widow mom that has taken control of my son thats 22 years of age without any help from the goverment as to having himliving home with me and endagering my life just to keep my boy here since he had alot of problems since birth? Suacidel, autisim, and now found out after him trying to jump out of my car as i was driving 60 iles on a highway and almost thought i was going to have a heart attack. Again back in the hospital and more money for mom to put out just because i love my son so much, but need more help finacially so we can still remain in our home here that me and my passed husband had built for us to live in. I need some good adive, am i m just getting my son his one check for him from disabilty and nothing for the mom that has stopped my life just to take care of my loved son.? Dont the goverment have to give me help for having him home with me and chancing my life as to him maybe killing me one day? Please help me with some answers. Sorry if im miss spelling but he is home and its so hard for me to just have quiet time without my son going on and on about the same things very minute. Great young man, just sooooo sad that now this hit him. I need help with a professinal that knows more of what i can do or if i can get or should have been getting help from the goverment for keeping my son home with me where i want him to be instead of a dam group home and no son to come home too? Need your opinion. Please. LOnely mom that dont know cwhere to turn anymore. Five Filters featured article: The Art of Looking Prime Ministerial - The 2010 UK General Election. Available tools: PDF Newspaper, Full Text RSS, Term Extraction. |
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